Analysis of Gene-Specific DNA Methylation Patterns in Cells Derived from Equine Adult and Fetal Tissues
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چکیده
Introduction: Cellular pluripotency is associated with expression of the homeobox transcription factor genes NANOG, SOX2 and POU5F1 (the gene that codes for Oct3/4 protein). Some reports suggest that mesenchymal progenitor cells (MPC) express increased quantities of these genes creating the possibility MPCs are more pluripotent than other adult cell types. The objective of this study was to determine if equine bone marrow-derived MPCs had gene expression or DNA methylation patterns that differed from either early fetal-derived or terminally differentiated adult cells.
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تاریخ انتشار 2011